Syrinx is a well- customizable Twitter client, which allows to adapt the appearance of the program and the individual tweets to your own needs. Moreover Syrinx has many features that enable optimal workflow for Twitter. Followers are e.g. displayed in a separate window with access to detailed information. The automated retrieval of tweets can easily be interrupted by pressing the "Pause-Button" and Tweets can be searched based on time.
Moreover Syrinx supports common Twitter functions like short URLs, re-tweet, and offers a Growl integration.